Abstract: Commerce always entails cultural exchange and intermingling. The Guangzhou trade was the important medium for the cultural exchange between China and the West. The exports of Chinese traditional goods represented thousands of years of cultural accumulation, not only embodying the exquisite crafts, but also implying the oriental customs and social visions. Chinese goods entered the Westerners’s everyday lives, such as diet and attire, and opened the Rococo Age. Meanwhile, European culture spread throughout southeastern coastal China. The manufacture of exports goods enabled Western religious stories and fairy tales to reach the Chinese people, and created artists who were familiar with Western artistic techniques. Western medicine and commercial culture were adopted by the Chinese who encountered them.