Abstract: This article argues that fishery regulation in the Qing Dynasty was directly related to the social turmoil of the late Ming and early Qing and the control of the people who lived in the Southeast coastal region, especially fishermen. In pursuit of their livelihood, fishermen challenged these restrictions, and their transgressions finally affected the transformation of the regulation. The author takes the transformation of the fishery regulation in Guangdong Province in early Qing Dynasty as a case and tries to exhume the complicated political, economic and social relationships between government regulation and the coastal society.